![]() A retrospective study report compared the characteristics of gout in Hmong patients versus Caucasians and examined if Hmong ethnicity is associated with risk of tophaceous gout.28 Wahedduddin S, Singh JA, Culhane-Pera KA, Gertner E.US Department of Commerce, Economics and Statistics Administration, WA, DC, USA, 23 ( 2012). Elevated CpG island methylation of GCK gene predicts the risk of Type 2 diabetes in Chinese males. The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver. 25 Beer NL, Tribble ND, McCulloch LJ et al.24 Reginato AM, Mount DB, Yang I, Choi HK.T6092C polymorphism of SLC22A12 gene is associated with serum uric acid concentrations in Korean male subjects. Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Maori, Pacific Island, and Caucasian case–control sample sets. 22 Hollis-Moffatt JE, Xu X, Dalbeth N et al.A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Maori, case and control sample sets. 21 Phipps-Green AJ, Hollis-Moffatt JE, Dalbeth N et al.Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese. Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population. 19 Graessler J, Graessler A, Unger S et al.Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. 18 Kottgen A, Albrecht E, Teumer A et al.The study identified nine genetic loci to be significantly associated with serum uric acid concentration. A key meta-analysis of genome-wide association studies that was conducted on primarily Caucasian individuals numbering 28,141.Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. The first report to estimate gout prevalence among the Minnesota Hmong using self report of gout and retrospective chart review, which were compared with the overall prevalence of gout across the nation.High prevalence of gouty arthritis among the Hmong population in Minnesota. 16 Portis AJ, Laliberte M, Tatman P et al.Recent trends in hyperuricemia and gout in Japan. 14 Klemp P, Stansfield SA, Castle B, Robertson MC.A genome-wide association study of serum uric acid in African Americans. 13 Charles BA, Shriner D, Doumatey A et al.A very concise review that summarizes the prevalence of gout across different races while highlighting some of the genetic and nongenetic factors that could contribute to such a large variability in gout prevalence.Racial and gender disparities among patients with gout. The role of hyperuricemia and gout in kidney and cardiovascular disease. New insights into the epidemiology of gout. Plasma uric acid is associated with increased risk of Type 2 diabetes independent of diet and metabolic risk factors. 9 Sluijs I, Beulens JW, van der A DL, Spijkerman AM, Schulze MB, van der Schouw YT.Association of serum uric acid with cardiovascular disease in rheumatoid arthritis. 7 Panoulas VF, Milionis HJ, Douglas KM et al.Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. 2012 American College of Rheumatology guidelines for management of gout. 6 Khanna D, Fitzgerald JD, Khanna PP et al.5 Alvarez-Lario B, Macarron-Vicente J.Genetics of hyperuricemia and gout: implications for the present and future. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007–2008. ![]() Comorbidities of gout and hyperuricemia in the US general population: NHANES 2007–2008. The epidemiology of uric acid and fructose. Papers of special note have been highlighted as:
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